The squad also includes Real Madrid midfielder Federico Valverde, Juventus midfielder Rodrigo Bentancur and Inter Milan defender Diego Godin.
The Baggies opened the scoring thanks to new signing Grady Diangana in the 10th minute, but Calvert-Lewin leveled with a back heel that was given after consultation with VAR.
The deadlock was finally broken with eight minutes to go, when a corner was nodded onto the path of defender Khalilzadeh, who was well-positioned at the far post to control and finish into the bottom corner.
Flamengo had never before lost a Copa Libertadores match by a five-goal margin. Previously, their worst showing in South America's premier club competition was a 5-1 capitulation to Gremio in 1984. Thursday's result was also the heaviest defeat by defending Copa Libertadores champions.
"To have kept the team together might turn into our big advantage," Borussia's managing director Max Eberl said.
"I don't think David is demanding to stand above those two," the 43-year-old said.
Kurt Zouma completed the scoring on 66 minutes, as his low shot from a corner was deflected past the unfortunate Ryan.
"These two tournaments came too close to each other for me this time," she added.
Tractor will participate at the next year's AFC Champions League qualification as the champions of Iran's Hazfi Cup. Enditem
Esteghlal parted company with Farhad Majidi at the end of Iran's super league season and reportedly has not reached an agreement with Italian coach Andrea Stramaccioni.
Talavera's return to the international fold comes after a series of impressive performances for Pumas UNAM, whom he joined from their Liga MX rivals Toluca in July.