The second half started similar to the first as Leverkusen were the more active team whereas the "Wolves" lurked for their chances.
Spain's 12-time French Open winner Nadal, who is bidding for a record-equaling 20th Grand Slam, will play world No. 83 Egor Gerasimov of Belarus in the first round.
Zinedine Zidane's side goes into the game on the back of a 0-0 draw away to Real Sociedad a week ago, in a game it controlled for long periods without creating the chances it needed to win.
The pair have not played for Colombia since the team's penalty shootout defeat to Chile in the quarterfinals of last year's Copa America in Brazil.
"Both players and staff are disappointed not to be able to get back on the field," US coach Gregg Berhalter said. "While COVID-19 continues to create challenges for us, we are confident we can find a way forward in the near future that will provide an opportunity to play matches in preparation for the important competitions next year."
The CONMEBOL zone qualifiers had been scheduled to begin in late March but were suspended amid the COVID-19 pandemic. Enditem
Semedo has agreed to a three-year contract until the end of June 2023, with the option to extend it until 2025. He will replace Matt Doherty, who recently joined Tottenham.
Atletico Madrid's pre-season hasn't been a bed of roses with coach Diego Simeone testing positive for COVID-19 and central defender Jose Gimenez also returning a positive test at the start of the week to complicate preparations for their league debut at home to an impressive Granada.
Leipzig, however, responded straight away and pressed Mainz on the back foot to restore their two-goal lead three minutes later as Haidara made no mistake to tap home Forsberg's square pass.
Given the atmosphere currently surrounding the Camp Nou, Koeman needs to start with a win, because if not things are not going to get any easier. Enditem
Shenhua doubled the lead eight minutes after the break when Peng's header found Bi Jinhao, who resisted a shoulder-to-shoulder challenge in the box to drill home.