Kevin de Bruyne was the Man of the Match for Guaridola's side, winning a penalty in the 19th minute and then sending Wolves keeper Rui Patricio the wrong way from the penalty spot.
But the draw was enough for Saint-Etienne to top the standings on goal difference over second-placed Rennes.
The Wolves took a hard-earned win and are now one victory away from booking their berth in the Europa League's group stage, as ten-man Desna were unable to cause surprise.
Guoan now sit second in Group B with 25 points, with two rounds in the first stage remaining. Guoan have booked a spot in Group C for the championship race. Enditem
Wander Helder scored twice for Leeds and Aleksander Mitrovic scored twice for the home side, who fought back from 4-1 down to give Leeds a nervy last 25 minutes.
Monday's match also saw Guangzhou R&F edge Dalian Pro 1-0 by Ye Chugui's late goal in the 92nd minute. The three points also helped R&F join the chase for fourth place in Dalian.
Zhou Junchen was brought down inside the box in the 54th minute. His teammate Romain Alessandrini then added the second goal for Huanghai by penalty.
Later on Wednesday, Jiangsu also defeated Yunnan 3-0 (25-8, 25-18, 25-20). However, their victory was not easy.
The 24-year-old striker has put to pen to paper on a five-year deal which binds him to the "Bulls" until June 2025.
‘ It [Chinese skiing] is like a child. I hope it can grow up healthily.’
Bruno Labbadia's men gained momentum but Frankfurt stood firm and protected its lead until the final whistle.